In the backwater town of Boone's Lick, Missouri, Mary Margaret has finally had it with her ne'er-do-well husband, Dickie - whose job supplying forts along the Oregon Trail gives him ample opportunity to be swayed out of his wedding vows. Determined to set things aright, she collects her children - along with the rest of her cantankerous kin - and makes her way West on a comic journey of epic proportions. Encountering every peril of life on the trail, Mary Margaret is about to show them all why hell hath no fury like a woman scorned.