Black holes. DNA. The Large Hadron Collider. Ever had that sneaking feeling that you are missing out on some truly spectacular science? You do? Well, fear not, for help is at hand. Ben Miller was working on his Physics PhD at Cambridge when he accidentally became a comedian. But first love runs deep, and he has returned to his roots to share with you all his favourite bits of science. This is the stuff you really need to know, not only because it matters but because it will quite simply amaze and delight you.