This book gathers the lecture notes of the 100th Les Houches Summer School, which was held in July 2013. These lectures represent a comprehensive pedagogical survey of the frontier of theoretical and observational cosmology just after the release of the first cosmological results of the Planck mission. The Cosmic Microwave Background is discussed as a possible window on the still unknown laws of physics at very high energy and as a backlight for studying the late-time Universe. Other lectures highlight connections of fundamental physics with other areas of cosmology and astrophysics, the successes and fundamental puzzles of the inflationary paradigm of cosmic beginning, the themes of dark energy and dark matter, and the theoretical developments and observational probes that will shed light on these cosmic conundrums in the years to come.