With the company on the brink of bankruptcy, the defiant president Echizen plans to do something foolish one last time. He sets up a lab he calls the "Orgasm Research Institute" and begins research into ecstasy with the researchers he has gathered. First, there is the interaction between Teruha, nicknamed "the 10,000-slayer" who charms men with sex, and Youji, who has a big dick. The excitement of the researchers reaches its peak when they see this. Then, they take turns to conduct dizzying experiments on pleasure in the isolation facility! What on earth lies ahead?!