Follow the adventures of Shiro Kazami, a bio-chem major at Jonan University in Tokyo. After witnessing the murder of a member of the evil organization Destron, Kazami is targeted by Destron which kills his family and leads him down a road of revenge that crosses paths with both Takeshi Hongo and Hayato Ichimonji, the original Kamen Riders and his eventual transformation into Kamen Rider V3!