Doggy Don is a little pink dog, who resides in the modern suburbs of South India. Unfortunately, he shares his house with three troublemaking mice: Chhotu, Lambu and Motu. Don is usually accompanied by his older brother, Colonel, who has a stronger grudge against the mice with his shorter temper, and Ballu, a cranky and aggressive Great Dane, who is Don's neighbor. Their adventures are usually some type of chaos that the mice produce and the havoc that ensues as the dogs attempt to stop the situation from escalating further, only to either make things worse or take the blame for the mice's shenanigans.