Pulled out of exile from a dark corner of the world, renowned-surgeon-turned-fringemedicine-eccentric Doctor Randal Horne must return to New York City to investigate a tragic research lab accident that's left one man dead, and inexplicably headless. Now with the help of a distrusting NYPD detective and a team of doctors from the CDC, Horne must diagnose this and other seemingly unexplainable medical phenomenon in a world where the line between medical science and science fiction is blurry at best.